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BNT162b2 mRNA SARS‐Covid‐2 vaccination does not cause upregulation of endothelial activation markers or hypercoagulability: A prospective, single‐arm, longitudinal study

journal contribution
posted on 2022-03-14, 01:42 authored by Xin Rong Lim, Pui Lam Bernard LeungPui Lam Bernard Leung, Christina Lai Lin Sum, Gek Hsiang Lim, Choon Guan Chua, Tian Ming Tu, Kollengode Ramanathan, Mei Yan Huang, Hwee Siew Howe, Bingwen Eugene Fan
Our findings provide reassuring preliminary data that BNT162b2 vaccination does not result in endothelial activation or a hypercoagulable state. While the definition and mechanism of (vaccine-induced thrombotic thrombocytopenia) VITT is more clearly defined and linked to the presence of PF4 antibodies, the cause of rare non-VITT thrombosis remains elusive. Additional studies will be required to identify the population at risk of vaccine associated thrombosis and how to monitor for this rare but serious complication.


This work was supported by a National Healthcare Group-National Centre for Infectious Diseases (NHG-NCID) COVID-19 Centre Grant (FY2021LXR).


Journal/Conference/Book title

American Journal of Hematology

Publication date



  • Post-print

Rights statement

This is the peer reviewed version of the following article: Lim, X. R., Leung, B. P., Sum, C., Lim, G. H., Chua, C. G., Tu, T. M., Ramanathan, K., Huang, M. Y., Howe, H. S., & Fan, B. E. (2022). BNT162b2 mRNA SARS-CoV-2 vaccination does not cause upregulation of endothelial activation markers or hypercoagulability: A prospective, single-arm, longitudinal study. American journal of hematology, which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.