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BNT162b2 mRNA SARS‐Covid‐2 vaccination does not cause upregulation of endothelial activation markers or hypercoagulability: A prospective, single‐arm, longitudinal study
journal contributionposted on 2022-03-14, 01:42 authored by Xin Rong Lim, Pui Lam Bernard LeungPui Lam Bernard Leung, Christina Lai Lin Sum, Gek Hsiang Lim, Choon Guan Chua, Tian Ming Tu, Kollengode Ramanathan, Mei Yan Huang, Hwee Siew Howe, Bingwen Eugene Fan
Our findings provide reassuring preliminary data that BNT162b2 vaccination does not result in endothelial activation or a hypercoagulable state. While the definition and mechanism of (vaccine-induced thrombotic thrombocytopenia) VITT is more clearly defined and linked to the presence of PF4 antibodies, the cause of rare non-VITT thrombosis remains elusive. Additional studies will be required to identify the population at risk of vaccine associated thrombosis and how to monitor for this rare but serious complication.
This work was supported by a National Healthcare Group-National Centre for Infectious Diseases (NHG-NCID) COVID-19 Centre Grant (FY2021LXR).
Journal/Conference/Book titleAmerican Journal of Hematology