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2023 SciR - Improved mineralization of dental enamel by electrokinetic delivery of F− and Ca2+ ions.pdf (1.15 MB)

Improved mineralization of dental enamel by electrokinetic delivery of F and Ca2+ ions

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posted on 2023-10-17, 03:05 authored by Nam Beng Tay, Hiong Yap GanHiong Yap Gan, Frederico Barbosa de Sousa, Lu ShenLu Shen, Diego Figueiredo Nóbrega, Chenhui Peng, LaTonya Kilpatrick-Liverman, Wei Wang, Stacey Lavender, Shira Pilch, Jongyoon Han

This in vitro study evaluated the effects of the infiltration of F- and Ca2+ ions into human enamel by electrokinetic flow (EKF) on the enamel microhardness and F- content. Sound human enamel ground sections of unerupted third molars were infiltrated with de-ionized water by EKF and with F- ion by EKF respectively. All samples were submitted to two successive transverse acid-etch biopsies (etching times of 30 s and 20 min) to quantify F- ion infiltrated deep into enamel. Remarkably, sound enamel showed a large increase in microhardness (MH) after infiltration of NaF (p < 0.00001) and CaCl2 (p = 0.013) by EKF. Additionally, NaF-EKF increased the remineralization in the lesion body of artificial enamel caries lesions compared to controls (p < 0.01). With the enamel biopsy technique, at both etching times, more F- ions were found in the EKF-treated group than the control group (p << 0.05), and more fluoride was extracted from deeper biopsies in the NaF-EKF group. In conclusion, our results show that EKF treatment is superior in transporting Ca2+ and F ions into sound enamel when compared to molecular diffusion, enhancing both the mineralization of sound enamel and the remineralization of artificial enamel caries.

Funding

Colgate Parmolive, USA research grant (Award number: 025804-00001)

History

Journal/Conference/Book title

Scientific Reports

Publication date

2023-01-10

Version

  • Published

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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

Corresponding author

Gan Hiong Yap

Project ID

  • 6541 (R-MIT-A403-001) Electrokinetic Flow in Normal Dental Enamel

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