Increased Platelet Activation demonstrated by Elevated CD36 and P-Selectin Expression in 1-Year Post-Recovered COVID-19 Patients.

SSY, Wang; K, Chee; SW, Wong; GB, Tan; H, Ang; Leung, Pui Lam Bernard; CW, Tan; K, Ramanathan; R, Dalan; C, Cheung; DC, Lye; BE, Young; ES, Yap; YW, Chia; BE, Fan; Investigators, COVID-19 Clotting and Bleeding

doi:10.1055/s-0043-1762578

Increased Platelet Activation demonstrated by Elevated CD36 and P-Selectin Expression in 1-Year Post-Recovered COVID-19 Patients.

journal contribution

posted on 2023-03-06, 05:44 authored by Wang SSY, Chee K, Wong SW, Tan GB, Ang H, Pui Lam Bernard LeungPui Lam Bernard Leung, Tan CW, Ramanathan K, Dalan R, Cheung C, Lye DC, Young BE, Yap ES, Chia YW, Fan BE, COVID-19 Clotting and Bleeding Investigators

COVID-19 associated hypercoagulability and platelet hyperactivity are characteristic of COVID-19 infection and contribute to an increased thrombotic burden. This clinical phenomenon is observed during acute illness and the immediate post-recovery period. In addition to findings of hypercoagulability, endotheliopathy, and inflammation from our previous study of 39 COVID-19 survivors at a time point approximating 1 year after their recovery from COVID-19, we evaluated the platelet activation profile of a subset of 36 patients, demonstrating increased platelet activation with elevated CD36 and P-Selectin expression compared to healthy individuals without COVID-19 infection.

Funding

This work was supported by a National Healthcare Group-National Centre for Infectious Diseases (NHG-NCID) COVID-19 Centre Grant (COVID19 CG008).

History

Journal/Conference/Book title

Seminars in Thrombosis and Hemostasis

Publication date

2023-02-01

Version

Published

Rights statement

This is the publisher's PDF version of: Wang, S.S.Y., K. Chee, S.W. Wong, G.B. Tan, H. Ang, B.P. Leung, C.W. Tan, K. Ramanathan, R. Dalan, C. Cheung, D.C. Lye, B.E. Young, E.S. Yap, Y.W. Chia, B.E. Fan, and COVID-19 Clotting Bleeding Investigators. 2023. Increased platelet activation demonstrated by elevated CD36 and P-selectin expression in 1-year post-recovered COVID-19 patients. Semin Thromb Hemost. https://doi.org/10.1055/s-0043-1762578.