Neutrophil-erythrocyte rosettes are rare. They are associated with autoimmune haemolytic anaemia (AIHA) and paroxysmal cold haemoglobinuria. The mechanism of neutrophil-erythrocyte rosettes in AIHA is still poorly defined. It is postulated to be due to a factor in the IgG fraction of immunoglobulin, primarily directed at some red blood cell surface antigen(s). To our knowledge, this is the first reported case of COVID-19 associated neutrophil-erythrocyte rosettes, given the temporal association of neutrophil erythrocyte rosettes with acute SARS-CoV-2 infection with resolution on convalescence, and is most likely secondary to an unidentified IgG antibody.
Journal/Conference/Book titleAmerican Journal of Hematology
Rights statementFan, B.E., J.Q.W. Leong, B.P.L. Leung, W.Y.Ng, W.L.S. Lian, W.Y.K. Wong, W.Y. Lim, S.P.C. Chen, S.Y.R. Yap, G.B. Tan, M. Chow, S.S. Mucheli, P. Kuperan, and C.A. Gallardo. (2022). Neutrophil-Erythrocyte Rosettes in COVID-19. American journal of Hematology, which has been published in final form at https://doi.org/10.1002/ajh.26637. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.