Singapore Institute of Technology

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Neutrophil‐Erythrocyte Rosettes in COVID‐19

journal contribution
posted on 2022-07-09, 01:37 authored by Bingwen Eugene Fan, Jia Qi Wendy Leong, Pui Lam Bernard LeungPui Lam Bernard Leung, Weng Yik Ng, Wendy Lim Siew Lian, Wei Yong Kevin Wong, Wei Yin Lim, Siew Ping Connie Chen, Sheem Ying Rachel Yap, Guat Bee Tan, Minyang Chow, Sharavan Sadasiv Mucheli, Ponnudurai Kuperan, Christian Aledia Gallardo

Neutrophil-erythrocyte rosettes are rare. They are associated with autoimmune haemolytic anaemia (AIHA) and paroxysmal cold haemoglobinuria. The mechanism of neutrophil-erythrocyte rosettes in AIHA is still poorly defined. It is postulated to be due to a factor in the IgG fraction of immunoglobulin, primarily directed at some red blood cell surface antigen(s). To our knowledge, this is the first reported case of COVID-19 associated neutrophil-erythrocyte rosettes, given the temporal association of neutrophil erythrocyte rosettes with acute SARS-CoV-2 infection with resolution on convalescence, and is most likely secondary to an unidentified IgG antibody.


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Journal/Conference/Book title

American Journal of Hematology

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  • Published

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Fan, B.E., J.Q.W. Leong, B.P.L. Leung, W.Y.Ng, W.L.S. Lian, W.Y.K. Wong, W.Y. Lim, S.P.C. Chen, S.Y.R. Yap, G.B. Tan, M. Chow, S.S. Mucheli, P. Kuperan, and C.A. Gallardo. (2022). Neutrophil-Erythrocyte Rosettes in COVID-19. American journal of Hematology, which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.

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