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Post COVID-19 Large Vessel Vasculopathy in a Previously Healthy Young Male.

journal contribution
posted on 2023-10-17, 01:41 authored by Fan BE, Mucheli SS, Tang YL, Yong E, Dalan R, Cheung C, Young BE, Lye DCB, Wang L, Tan CW, Lim KHT, Sum CLL, Gallardo CA, Christopher D, Pui Lam Bernard LeungPui Lam Bernard Leung, COVID-19 Clotting and Bleeding Investigators

The rising incidence of thrombosis post-coronavirus disease 2019 (COVID-19) places an increased burden on health care systems, as even young patients with prior asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can suffer from delayed catastrophic thrombosis. Mechanistically, post-COVID-19 thrombosis may arise from persistent thromboinflammation, in turn arising from chronic hypercoagulability, endothelial dysfunction, inflammation, neutrophil extracellular trap formation, and platelet hyperactivation, which are detectable in some patients who have recovered from COVID-19. Here, we present radiological and histopathological evidence of chronic, large vessel vasculopathy associated with recurrent post-COVID-19 thrombosis in a young male.

Funding

This work was supported by a National Healthcare Group-National Centre for Infectious Diseases (NHG-NCID) COVID-19 Centre Grant (COVID19 CG008).

History

Journal/Conference/Book title

Seminars in Thrombosis and Hemostasis

Publication date

2023-09-01

Version

  • Published

Rights statement

This is the publisher's PDF version of: Fan, B. E., S. S. Mucheli, Y. L. Tang, E. Yong, R. Dalan, C. Cheung, B. E. Young, D. C. B. Lye, L. Wang, C. W. Tan, K. H. T. Lim, C. L. L. Sum, C. A. Gallardo, D. Christopher, B. P. Leung, X. R. Lim, S. W. Wong, Y. W. Chia, V. C. L. Chong, and COVID-19 Clotting and Bleeding Investigators. 2023. Post COVID-19 Large Vessel Vasculopathy in a Previously Healthy Young Male. Semin Thromb Hemost. https://doi.org/ 10.1002/ajh.26773.

Corresponding author

Dr Eugene Bingwen Fan

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