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Residual humoral immunity sustained over decades in a cohort of vaccinia-vaccinated individuals.

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posted on 2022-10-11, 05:41 authored by Chan CEZ, Wong SKK, Yazid NBM, Ng OT, Marimuthu K, Chan M, Howe HS, Leo YS, Pui Lam Bernard LeungPui Lam Bernard Leung, Vasoo SS, Young BE

In 2019, Singapore experienced a case of imported Monkeypox. As with smallpox, disease can be prevented through vaccination, which was mandatory for Singaporean infants until 1981. However, the degree of residual immunity in older vaccinated Singaporeans remains unknown. Sera from individuals born from 1946-1984 were therefore tested and those born prior to 1981 were found to have higher anti-vaccinia IgG and neutralizing activity titres. This suggests that protective humoral immunity remains which could reduce disease severity in an orthopoxvirus outbreak. Correlation between IgG and neutralizing titres was observed indicating that serology could be used as a surrogate marker for immunity.  

Funding

This work was supported by funding from RIE2020 Collaborative Centre Grant Seed Funding Programme FY2019/20 (Grant No. CCGSFP19001).

History

Journal/Conference/Book title

The Journal of infectious diseases

Publication date

2022-10-01

Version

  • Post-print

Rights statement

This is the publisher's PDF version of: Chan, C. E. Z., S. K. K. Wong, N. B. M. Yazid, O. T. Ng, K. Marimuthu, M. Chan, H. S. Howe, Y. S. Leo, B. P. Leung, S. S. Vasoo, and B. E. Young. 2022. Residual humoral immunity sustained over decades in a cohort of vaccinia-vaccinated individuals. J Infect Dis. Oct 6:jiac409. doi: 10.1093/infdis/jiac409

Corresponding author

Dr Conrad EZ Chan (National Centre for Infectious Diseases) Conrad_EZ_CHAN@ncid.sg

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