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Understanding the Adsorption and Desorption of Sitagliptin Phosphate Monohydrate on SS2343, Glass, and PTFE Using QCM-D and Raman Spectroscopy

journal contribution
posted on 2023-11-07, 02:07 authored by Hui Ling Chan, Darrel Po Rong Len, Shuying Cheng, Jin Wang Kwek, Valerio IsoniValerio Isoni, Beng Joo Reginald ThioBeng Joo Reginald Thio

Cross-contamination during pharmaceutical drug manufacturing can result in expensive recalls. To counter that, companies spend significant time and resources to ensure equipment cleanliness, often relying on the compound solubility data in various solvents as the main indicator of cleaning success. The aim of this work is to provide an alternative way to analyze the fouling and cleaning of surfaces in pharmaceutical manufacturing processes by using the quartz crystal microbalance with dissipation (QCM-D) and Raman spectroscopy. 

History

Journal/Conference/Book title

Langmuir

Publication date

2022-08-19

Version

  • Published

Corresponding author

Beng Joo Reginald Thio

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