Research Interest: (1) Role of inflammatory cytokines in the development of autoimmunity, allergy, and ageing; (2) Role of immunomodulators in experimental inflammatory conditions. Based on a range of translational programmes from biomarker study, in vivo and in vitro assays, this allow me to study different aspect of the immune system and how it interact with the host in health and disease.

Publications

  • Association of nutrition and immune-endocrine dysfunction with muscle mass and performance in cognitively impaired older adults
  • Associations of B cell-activating factor (BAFF) and anti-BAFF autoantibodies with disease activity in multi-ethnic Asian systemic lupus erythematosus patients in Singapore
  • The effect of nerve mobilization exercise in patients with rheumatoid arthritis: a pilot study
  • Monocyte chemoattractant protein-1: a proinflammatory cytokine elevated in sarcopenic obesity
  • Sex-specific differences in risk factors for sarcopenia amongst community-dwelling older adults
  • The Case for Stage-Specific Frailty Interventions Spanning Community Aging to Cognitive Impairment
  • TLR Cross-talk Confers Specificity to Innate Immunity
  • Laminin drives survival signals to promote a contractile smooth muscle phenotype and airway hyperreactivity
  • Receptor-Interacting Protein 2 Gene Silencing Attenuates Allergic Airway Inflammation
  • The synergy in cytokine production through MyD88-TRIF pathways is co-ordinated with ERK phosphorylation in macrophages
  • Fisetin, a bioactive flavonol, attenuates allergic airway inflammation through negative regulation of NF-kappa B
  • Resveratrol modulates murine collagen-induced arthritis by inhibiting Th17 and B-cell function
  • Sphingosine kinase and sphingosine-1-phosphate receptors: novel therapeutic targets of rheumatoid arthritis?
  • Urine sVCAM-1 and sICAM-1 levels are elevated in lupus nephritis
  • Anti-Malarial Drug Artesunate Attenuates Experimental Allergic Asthma via Inhibition of the Phosphoinositide 3-Kinase/Akt Pathway
  • Heat-shock protein 60 translocates to the surface of apoptotic cells and differentiated megakaryocytes and stimulates phagocytosis
  • Phosphodiesterase 4 (PDE4) regulation of proinflammatory cytokine and chemokine release from rheumatoid synovial membrane
  • Serum Monocyte Chemotactic Protein-1 Concentrations Distinguish Patients With Ankylosing Spondylitis From Patients With Mechanical Low Back Pain
  • Sphingosine kinase and sphingosine 1-phosphate in asthma
  • IL-33 Exacerbates Autoantibody-Induced Arthritis
  • SARM inhibits both TRIF- and MyD88-mediated AP-1 activation
  • A Novel Antiinflammatory Role for Andrographolide in Asthma via Inhibition of the Nuclear Factor-kappa B Pathway
  • Distinct Roles of Sphingosine Kinase 1 and 2 in Murine Collagen-Induced Arthritis
  • Enhanced expression of interferon-inducible protein-10 correlates with disease activity and clinical manifestations in systemic lupus erythematosus
  • Anti-Inflammatory Effects of Sphingosine Kinase Modulation in Inflammatory Arthritis
  • Interleukin 27 attenuates collagen-induced arthritis
  • The role of sphingosine kinase in a murine model of allergic asthma
  • Glycogen synthase kinase-3 beta inhibition attenuates asthma in mice
  • IL-15 mediates antigen-induced neutrophil migration by triggering IL-18 production
  • IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells
  • CD4(+)CD25(+) regulatory T cells in health and disease
  • An anti-inflammatory role for a phosphoinositide 3-kinase inhibitor LY294002 in a mouse asthma model
  • Expression profile of immune response genes in patients with Severe Acute Respiratory Syndrome
  • Inhaled p38 alpha mitogen-activated protein kinase antisense oligonucleotide attenuates asthma in mice
  • Novel immunofluorescence assay using recombinant nucleocapsid-spike fusion protein as antigen to detect antibodies against severe acute respiratory syndrome coronavirus
  • Prior elevation of IL-18 promotes rapid early IFN-gamma production during staphylococcal infection
  • Transforming growth factor beta-1 and gene polymorphisms in oriental ankylosing spondylitis
  • A novel anti-inflammatory role of simvastatin in a murine model of allergic asthma
  • A novel therapy of murine collagen-induced arthritis with soluble T1/ST2
  • Anti-inflammatory effects of mitogen-activated protein kinase kinase inhibitor U0126 in an asthma mouse model
  • Development of a Western blot assay for detection of antibodies against coronavirus causing severe acute respiratory syndrome
  • Immunological characterization of the spike protein of the severe acute respiratory syndrome coronavirus
  • A brief report on the clinical trial on neural mobilization exercise for joint pain in patients with rheumatoid arthritis
  • Serum Myostatin and IGF-1 as Gender-Specific Biomarkers of Frailty and Low Muscle Mass in Community-Dwelling Older Adults
  • Elevations in Serum Dickkopf-1 and Disease Progression in Community-Dwelling Older Adults With Mild Cognitive Impairment and Mild-to-Moderate Alzheimer’s Disease
  • Serum IL-6 and circulating immune complexes as biomarkers of disease activity in multi-ethnic asian systemic lupus erythematosus
  • Inter-muscular adipose tissue is associated with adipose tissue inflammation and poorer functional performance in central adiposity
  • Promises and challenges of biologics for severe asthma
  • Anti-cytokine autoantibodies in systemic lupus erythematosus
  • Association of Monocyte Chemotactic Protein-1 and Dickkopf-1 with Body Composition and Physical Performance in Community-Dwelling Older Adults in Singapore.
  • A novel anti-inflammatory role for simvastatin in inflammatory arthritis
  • A novel therapeutic approach targeting articular inflammation using the filarial nematode-derived phosphorylcholine-containing glycoprotein ES-62
  • IL-18 enhances collagen-induced arthritis by recruiting neutrophils via TNF-alpha and leukotriene B-4
  • A novel dendritic cell-induced model of erosive inflammatory arthritis: Distinct roles for dendritic cells in T cell activation and induction of local inflammation
  • Enhanced Th1 response to Staphylococcus aureas infection in human lactoferrin-transgenic mice
  • Novel pathways that regulate tumor necrosis factor-alpha production in rheumatoid arthritis
  • A novel pathway regulating lipopolysaccharide-induced shock by ST2/T1 via inhibition of toll-like receptor 4 expression
  • A role for IL-18 in neutrophil activation
  • Reduced incidence and severity of collagen-induced arthritis in mice lacking IL-18
  • The sushi domain of soluble IL-15 receptor alpha is essential for binding IL-15 and inhibiting inflammatory and allogenic responses in vitro and in vivo
  • Cell-cell interactions in synovitis - Interactions between T lymphocytes and synovial cells
  • Combined effects of IL-12 and IL-18 on the induction of collagen-induced arthritis
  • IL-18 induces the differentiation of Th1 or Th2 cells depending upon cytokine milieu and genetic background
  • Interleukin 18: a pleiotropic participant in chronic inflammation
  • A proinflammatory role for IL-18 in rheumatoid arthritis
  • Altered immune responses and susceptibility to Leishmania major and Staphylococcus aureus infection in IL-18-deficient mice
  • Thymosin beta 4 sulfoxide is an anti-inflammatory agent generated by monocytes in the presence of glucocorticoids
  • A role for IL-15 in rheumatoid arthritis? Reply
  • Selective expression and functions of interleukin 18 receptor on T helper (Th) type 1 but not Th2 cells
  • Selective expression of a stable cell surface molecule on type 2 but not type 1 helper T cells
  • Septic arthritis following Staphylococcus aureus infection in mice lacking inducible nitric oxide synthase
  • Soluble IL-15 receptor alpha-chain administration prevents murine collagen-induced arthritis: A role for IL-15 in development of antigen-induced immunopathology
  • Altered interleukin 12 and nitric oxide levels in recurrent miscarriage
  • Interleukin-15 mediates T cell-dependent regulation of tumor necrosis factor-alpha production in rheumatoid arthritis
  • Production of nitric oxide in the synovial membrane of rheumatoid and osteoarthritis patients
  • The role of interleukin-15 in T-cell migration and activation in rheumatoid arthritis
  • Inducing experimental arthritis and breaking self-tolerance, to joint-specific antigens with trackable, ovalbumin-specific T cells
  • The anti-inflammatory potential of the filarial nematode secreted product, ES-62

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