Research Interest: (1) Role of inflammatory cytokines in the development of autoimmunity, allergy, and ageing; (2) Role of immunomodulators in experimental inflammatory conditions.

Publications

  • Association of nutrition and immune-endocrine dysfunction with muscle mass and performance in cognitively impaired older adults
  • Associations of B cell-activating factor (BAFF) and anti-BAFF autoantibodies with disease activity in multi-ethnic Asian systemic lupus erythematosus patients in Singapore
  • The effect of nerve mobilization exercise in patients with rheumatoid arthritis: a pilot study
  • Monocyte chemoattractant protein-1: a proinflammatory cytokine elevated in sarcopenic obesity
  • Sex-specific differences in risk factors for sarcopenia amongst community-dwelling older adults
  • The Case for Stage-Specific Frailty Interventions Spanning Community Aging to Cognitive Impairment
  • TLR Cross-talk Confers Specificity to Innate Immunity
  • Laminin drives survival signals to promote a contractile smooth muscle phenotype and airway hyperreactivity
  • Receptor-Interacting Protein 2 Gene Silencing Attenuates Allergic Airway Inflammation
  • The synergy in cytokine production through MyD88-TRIF pathways is co-ordinated with ERK phosphorylation in macrophages
  • Fisetin, a bioactive flavonol, attenuates allergic airway inflammation through negative regulation of NF-kappa B
  • Resveratrol modulates murine collagen-induced arthritis by inhibiting Th17 and B-cell function
  • Sphingosine kinase and sphingosine-1-phosphate receptors: novel therapeutic targets of rheumatoid arthritis?
  • Urine sVCAM-1 and sICAM-1 levels are elevated in lupus nephritis
  • Anti-Malarial Drug Artesunate Attenuates Experimental Allergic Asthma via Inhibition of the Phosphoinositide 3-Kinase/Akt Pathway
  • Heat-shock protein 60 translocates to the surface of apoptotic cells and differentiated megakaryocytes and stimulates phagocytosis
  • Phosphodiesterase 4 (PDE4) regulation of proinflammatory cytokine and chemokine release from rheumatoid synovial membrane
  • Serum Monocyte Chemotactic Protein-1 Concentrations Distinguish Patients With Ankylosing Spondylitis From Patients With Mechanical Low Back Pain
  • Sphingosine kinase and sphingosine 1-phosphate in asthma
  • IL-33 Exacerbates Autoantibody-Induced Arthritis
  • SARM inhibits both TRIF- and MyD88-mediated AP-1 activation
  • A Novel Antiinflammatory Role for Andrographolide in Asthma via Inhibition of the Nuclear Factor-kappa B Pathway
  • Distinct Roles of Sphingosine Kinase 1 and 2 in Murine Collagen-Induced Arthritis
  • Enhanced expression of interferon-inducible protein-10 correlates with disease activity and clinical manifestations in systemic lupus erythematosus
  • Anti-Inflammatory Effects of Sphingosine Kinase Modulation in Inflammatory Arthritis
  • Interleukin 27 attenuates collagen-induced arthritis
  • The role of sphingosine kinase in a murine model of allergic asthma
  • Glycogen synthase kinase-3 beta inhibition attenuates asthma in mice
  • IL-15 mediates antigen-induced neutrophil migration by triggering IL-18 production
  • IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells
  • CD4(+)CD25(+) regulatory T cells in health and disease
  • An anti-inflammatory role for a phosphoinositide 3-kinase inhibitor LY294002 in a mouse asthma model
  • Expression profile of immune response genes in patients with Severe Acute Respiratory Syndrome
  • Inhaled p38 alpha mitogen-activated protein kinase antisense oligonucleotide attenuates asthma in mice
  • Novel immunofluorescence assay using recombinant nucleocapsid-spike fusion protein as antigen to detect antibodies against severe acute respiratory syndrome coronavirus
  • Prior elevation of IL-18 promotes rapid early IFN-gamma production during staphylococcal infection
  • Transforming growth factor beta-1 and gene polymorphisms in oriental ankylosing spondylitis
  • A novel anti-inflammatory role of simvastatin in a murine model of allergic asthma
  • A novel therapy of murine collagen-induced arthritis with soluble T1/ST2
  • Anti-inflammatory effects of mitogen-activated protein kinase kinase inhibitor U0126 in an asthma mouse model
  • Development of a Western blot assay for detection of antibodies against coronavirus causing severe acute respiratory syndrome
  • Immunological characterization of the spike protein of the severe acute respiratory syndrome coronavirus
  • A brief report on the clinical trial on neural mobilization exercise for joint pain in patients with rheumatoid arthritis
  • Serum Myostatin and IGF-1 as Gender-Specific Biomarkers of Frailty and Low Muscle Mass in Community-Dwelling Older Adults
  • Elevations in Serum Dickkopf-1 and Disease Progression in Community-Dwelling Older Adults With Mild Cognitive Impairment and Mild-to-Moderate Alzheimer’s Disease
  • Serum IL-6 and circulating immune complexes as biomarkers of disease activity in multi-ethnic asian systemic lupus erythematosus
  • Inter-muscular adipose tissue is associated with adipose tissue inflammation and poorer functional performance in central adiposity
  • Promises and challenges of biologics for severe asthma
  • Anti-cytokine autoantibodies in systemic lupus erythematosus
  • Association of Monocyte Chemotactic Protein-1 and Dickkopf-1 with Body Composition and Physical Performance in Community-Dwelling Older Adults in Singapore.
  • A novel anti-inflammatory role for simvastatin in inflammatory arthritis
  • A novel therapeutic approach targeting articular inflammation using the filarial nematode-derived phosphorylcholine-containing glycoprotein ES-62
  • IL-18 enhances collagen-induced arthritis by recruiting neutrophils via TNF-alpha and leukotriene B-4
  • A novel dendritic cell-induced model of erosive inflammatory arthritis: Distinct roles for dendritic cells in T cell activation and induction of local inflammation
  • Enhanced Th1 response to Staphylococcus aureas infection in human lactoferrin-transgenic mice
  • Novel pathways that regulate tumor necrosis factor-alpha production in rheumatoid arthritis
  • A novel pathway regulating lipopolysaccharide-induced shock by ST2/T1 via inhibition of toll-like receptor 4 expression
  • A role for IL-18 in neutrophil activation
  • Reduced incidence and severity of collagen-induced arthritis in mice lacking IL-18
  • The sushi domain of soluble IL-15 receptor alpha is essential for binding IL-15 and inhibiting inflammatory and allogenic responses in vitro and in vivo
  • Cell-cell interactions in synovitis - Interactions between T lymphocytes and synovial cells
  • Combined effects of IL-12 and IL-18 on the induction of collagen-induced arthritis
  • IL-18 induces the differentiation of Th1 or Th2 cells depending upon cytokine milieu and genetic background
  • Interleukin 18: a pleiotropic participant in chronic inflammation
  • A proinflammatory role for IL-18 in rheumatoid arthritis
  • Altered immune responses and susceptibility to Leishmania major and Staphylococcus aureus infection in IL-18-deficient mice
  • Thymosin beta 4 sulfoxide is an anti-inflammatory agent generated by monocytes in the presence of glucocorticoids
  • A role for IL-15 in rheumatoid arthritis? Reply
  • Selective expression and functions of interleukin 18 receptor on T helper (Th) type 1 but not Th2 cells
  • Selective expression of a stable cell surface molecule on type 2 but not type 1 helper T cells
  • Septic arthritis following Staphylococcus aureus infection in mice lacking inducible nitric oxide synthase
  • Soluble IL-15 receptor alpha-chain administration prevents murine collagen-induced arthritis: A role for IL-15 in development of antigen-induced immunopathology
  • Altered interleukin 12 and nitric oxide levels in recurrent miscarriage
  • Interleukin-15 mediates T cell-dependent regulation of tumor necrosis factor-alpha production in rheumatoid arthritis
  • Production of nitric oxide in the synovial membrane of rheumatoid and osteoarthritis patients
  • The role of interleukin-15 in T-cell migration and activation in rheumatoid arthritis
  • Inducing experimental arthritis and breaking self-tolerance, to joint-specific antigens with trackable, ovalbumin-specific T cells
  • The anti-inflammatory potential of the filarial nematode secreted product, ES-62

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