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Development of immediate and chronic spontaneous urticaria following mRNA COVID-19 vaccination: Tolerability of revaccination and immunological study

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posted on 2024-06-03, 07:36 authored by Ryan Xuan Wei Teo, Pui Lam Bernard LeungPui Lam Bernard Leung, Bernard Yu-Hor Thong, Justina Wei Lynn Tan, Grace Yin Lai Chan, Xin Rong Lim

Coronavirus 2019 (COVID-19) vaccination remains one of the key public health measures against the SARS-CoV-2 infection, significantly reducing illness severity and mortality rates. Urticaria and/or angioedema are cutaneous reactions that have been reported in response to messenger RNA (mRNA) COVID-19 vaccination and potentially affect fitness for revaccination.1 The development of chronic spontaneous urticaria (CSU) post-COVID-19 vaccination2 may further discourage patients from revaccination or preclude revaccination to keep vaccinations updated. We describe a Singapore case series of 64 patients with urticaria post-COVID-19 vaccination, studying patient tolerance to revaccination, immunological profile and development of CSU.

History

Journal/Conference/Book title

Annals of the Academy of Medicine, Singapore

Publication date

2024-01-30

Version

  • Published

Rights statement

This is the publisher's PDF version of: Teo, R. X. W., B. P. L. Leung, B. Y. H. Thong, J. W. L. Tan, G. Y. L. Chan, and X. R. Lim. 2024. Development of immediate and chronic spontaneous urticaria following mRNA COVID-19 vaccination: Tolerability of revaccination and immunological study. Ann Acad Med Singap 53: 57-59. https://doi.org/10.47102/annals-acadmedsg.2023249

Corresponding author

Dr Xin Rong Lim, Department of Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, 11 Jln Tan Tock Seng, Singapore 308433. Email: xin_rong_lim@ttsh.com.sg

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