Singapore Institute of Technology

Ping Liao

Clinician Scientist


  • TRPM4 channel and cancer
  • Brain‐derived neurotrophic factor and post‐stroke depression
  • TRPM4-specific blocking antibody attenuates reperfusion injury in a rat model of stroke
  • Binding epitope for recognition of human TRPM4 channel by monoclonal antibody M4M
  • Development and characterization of a monoclonal antibody blocking human TRPM4 channel
  • Comparison of Anti-oncotic Effect of TRPM4 Blocking Antibody in Neuron, Astrocyte and Vascular Endothelial Cell Under Hypoxia
  • TRPM4 inhibition improves spatial memory impairment and hippocampal long-term potentiation deficit in chronic cerebral hypoperfused rats
  • Alternative Splicing of the CaV1.3 Channel IQ Domain, a Molecular Switch for Ca2+-Dependent Inactivation within Auditory Hair Cells
  • Activation of Corticotropin-Releasing Factor Receptor 1 Selectively Inhibits CaV3.2 T-Type Calcium Channels
  • Alternative splicing modulates diltiazem sensitivity of cardiac and vascular smooth muscle Cav1.2 calcium channels
  • Cancer-associated fibroblasts in acute leukemia
  • Oncotic Cell Death in Stroke
  • Insights into the neuropathology of cerebral ischemia and its mechanisms
  • Nanocarriers for Stroke Therapy: Advances and Obstacles in Translating Animal Studies
  • Regulation of Blood Pressure by Targeting Ca V 1.2-Galectin-1 Protein Interaction
  • Clitoria ternatea L. root extract ameliorated the cognitive and hippocampal long-term potentiation deficits induced by chronic cerebral hypoperfusion in the rat
  • Exclusion of alternative exon 33 of CaV1.2 calcium channels in heart is proarrhythmogenic
  • Non-Invasive Multimodality Imaging Directly Shows TRPM4 Inhibition Ameliorates Stroke Reperfusion Injury
  • Characterization of CaV1.2 exon 33 heterozygous knockout mice and negative correlation between Rbfox1 and CaV1.2 exon 33 expressions in human heart failure
  • Aberrant Splicing Promotes Proteasomal Degradation of L-type CaV1.2 Calcium Channels by Competitive Binding for CaVβ Subunits in Cardiac Hypertrophy
  • Chronic cerebral hypoperfusion enhances Tau hyperphosphorylation and reduces autophagy in Alzheimer’s disease mice
  • Genetic Interactions Between TRPC6 and NPHS1 Variants Affect Posttransplant Risk of Recurrent Focal Segmental Glomerulosclerosis
  • Alternative Splicing Generates a Novel Truncated Cav1.2 Channel in Neonatal Rat Heart
  • CaV1.2 channelopathies: from arrhythmias to autism, bipolar disorder, and immunodeficiency
  • Brain transient receptor potential channels and stroke
  • Time course of motor and cognitive functions after chronic cerebral ischemia in rats
  • Calcium ion influx in microglial cells: Physiological and therapeutic significance
  • Therapeutic Antibodies in Stroke
  • TRPM4 inhibition promotes angiogenesis after ischemic stroke
  • Calfacilitin is a calcium channel modulator essential for initiation of neural plate development
  • Absence of Calcium Channel α1C-Subunit Mutation in Human Atrial Fibrillation
  • Splice Variant Specific Modulation of CaV1.2 Calcium Channel by Galectin-1 Regulates Arterial Constriction
  • Understanding alternative splicing of Cav1.2 calcium channels for a new approach towards individualized medicine
  • Alternative splicing of voltage-gated calcium channels: from molecular biology to disease
  • Molecular alteration of Cav1.2 calcium channel in chronic myocardial infarction
  • Differential splicing patterns of L-Type calcium channel Cav1.2 subunit in hearts of Spontaneously Hypertensive Rats and Wistar Kyoto rats
  • A Smooth Muscle Cav1.2 Calcium Channel Splice Variant Underlies Hyperpolarized Window Current and Enhanced State-dependent Inhibition by Nifedipine
  • Smooth Muscle-selective Alternatively Spliced Exon Generates Functional Variation in Cav1.2 Calcium Channels
  • Splicing for alternative structures of Ca1.2 Ca channels in cardiac and smooth muscles
  • SLC26A11 Inhibition Reduces Oncotic Neuronal Death and Attenuates Stroke Reperfusion Injury
  • TRPM4 Blocking Antibody Protects Cerebral Vasculature in Delayed Stroke Reperfusion
  • TRPM4 blocking antibody reduces neuronal excitotoxicity by specifically inhibiting glutamate-induced calcium influx under chronic hypoxia
  • In vivo evaluation of monoclonal antibody M4M using a humanised rat model of stroke demonstrates attenuation of reperfusion injury via blocking human TRPM4 channel
  • Effects of clitorienolactones from Clitoria ternatea root on calcium channel mediating hippocampal long-term potentiation in rats induced chronic cerebral hypoperfusion.
  • Enhanced isradipine sensitivity in vascular smooth muscle cells due to hypoxia‐induced Cav1.2 splicing and RbFox1/Fox2 downregulation

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Co-workers & collaborators

Thiam Huat Andy Lee

Thiam Huat Andy Lee

Ping Liao's public data